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KMID : 0360220080490020333
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 2 p.333 ~ p.339
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Ocular Concentration after Subtenon and Intravitreal Injection of Triamcinolone Acetonide in Rabbits
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Park Yong-Wook
Lim Jung-Hooon
Shin Jae-Pil
Kim Si-Yeol
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Abstract
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Purpose : To improve our understanding of the pharmacokinetics of triamcinolone acetonide (TA) and TA
concentration in ocular tissue, TA concentration was measured in ocular tissue after intravitreal and subtenon
injection.
Methods : Fifteen rabbit eyes underwent subtenon TA injection (40 mg/1 ml), and another 15 rabbit eyes
underwent intravitreal TA (4 mg/0.1 ml) injection. All eyes were enucleated at 1, 2, 4, 8, and 12 weeks after
subtenon and intravitreal injection, and TA concentration in the aqueous and vitreous humor and the
retina-choroid were measured by high performance liquid chromatography (HPLC).
Results : In cases of subtenon’s TA injection, TA concentrations were 0 ng/ml, 136.7 ng/ml, 178.7 ng/ml, 0
ng/ml, and 0 ng/ml in the aqueous humor; 99.1 ng/ml, 125.7 ng/ml, 726.8 ng/ml, 0 ng/ml, and 0 ng/ml in
the vitreous humor; 72.7 ng/ml, 304.6 ng/ml, 459.0 ng/ml, 0 ng/ml, and 0 ng/ml in the retina-choroid after
1, 2, 4, 8, and 12 weeks, respectively. In cases of intravitreal TA injection, the measured values were 0 ng/ml,
0 ng/ml, 0 ng/ml, 654.1 ng/ml, and 0 ng/ml in the aqueous humor; 28152.2 ng/ml, 13646.4 ng/ml, 11388.8
ng/ml, 10297.2 ng/ml, and 183.0 ng/ml in the vitreous humor; and 0 ng/ml, 27.9 ng/ml, 108.3 ng/ml, 0 ng/ml,
and 0 ng/ml in the retina-choroid at each time point.
Conclusion : Intravitreal TA injection may be more effective for drug delivery than subtenon TA injection,
but subtenon TA injection seems to be an effective and safe technique.
J Korean Ophthalmol Soc 49(2):333-339, 2008
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KEYWORD
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Intravitreal injection, Subtenon injection, Triamcinolone acetonide
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